The group - friends since high school now in their 20s - was returning from a nearby winery on Long Island's East End on Sunday.
Their driver was trying to make a U-turn at an intersection along Route 48 on Long Island's North Shore when the pickup slammed into the limo, authorities said.
In the mangled metal and glass wreckage, four of the women survived and were hospitalised, along with both drivers.
The pick-up driver, Steven Romeo, was arraigned at his hospital bedside at Eastern Long Island Hospital in Greenport on one misdemeanor charge of driving while intoxicated and ordered held on US$500,000 cash bail or US$1 million bond.
His lawyer was not immediately available for comment.
Chief Martin Flatley of Southold, Long Island, identified the dead as Brittany M. Schulman, 23, of Smithtown, on Long Island's North Shore; Lauren Baruch, 24, also of Smithtown; Stephanie Belli, 23, of nearby Kings Park; and Amy R. Grabina, 23, of Commack, also on the North Shore.
He said the young women had been friends for years, as far back as high school, and they had taken this kind of winery tour before.
"She was in the wrong place at the wrong time," he said of his daughter. "We loved her more than anything. Now I've got to bury my daughter."
Injured survivors include the driver of the limousine, Carlos Pino, 58, of Bethpage, Long Island, and four young women.
The police chief identified them as Joelle Dimonte, 25, of Elwood, Long Island; Melissa Angela Crai, 23, of Scarsdale, in Westchester County north of New York City; Alicia Arundel, 24, of Setauket, Long Island; and Olga Lipets, 24, of Brooklyn, New York.
The driver of the pic-kup hit the brakes before the crash but could not stop in time, Flatley said.
The chief said Romeo ran from the crash scene, but was caught and arrested.
Romeo is a co-owner of Romeo Dimon Marine Services in Southold, Long Island.
The police chief said the crash was "one of the worst accidents I've ever seen." The Suffolk County district attorney planned a news conference Monday to brief reporters on the ongoing investigation.

