The rebels, known as Houthis, and their allies started shelling the town of Dar Saad on Sunday after earlier losing control of some of Aden's neighborhoods. The violence highlighted the bloody chaos of the civil war gripping the Arab world's poorest country, which also has been the target of Saudi-led, U.S.-backed airstrikes since late March.
Hassan Boucenine of the Geneva-based Doctors Without Borders said that by Monday, his organisation reported nearly 100 people dead, twice the casualty toll from the previous day.
The shelling also wounded about 200 people, said Boucenine, the head of the organisation in Yemen.
"Yesterday was the worst day in Aden since (the Saudi-led coalition campaign) started in March," Boucenine told The Associated Press, adding that he fears "attacks on civilians will continue."
Sunday's shelling in Dar Saad began after the Houthi rebels lost control of much of the Aden district of Tawahi, according to officials and witnesses. Tawahi is now under a security lockdown, the officials said, as anti-Houthi forces search buildings looking for rebels, some of whom had fled to the nearby mountains.
The coalition also struck the home of Mehdi Meqlawa, a prominent supporter of former President Ali Abdullah Saleh, in a Sanaa suburb. In the Yemeni capital, it also hit Houthi headquarters near the Souq Aziz market, killing one person.
Rebel shelling continued Monday in Taiz, Yemen's third-largest city, killing eight residents, while ground fighting raged on in Marib, with six anti-Houthi tribesmen and 10 Houthi fighters killed in clashes. All officials and eyewitnesses spoke on condition of anonymity because they were not authorised to talk to reporters or feared reprisals.
Houthi officials declined to comment on the fighting.
The spokesman of the Yemeni government in exile, Rageh Badie, said they appointed the head of the Resistance Council, Nayef al-Bakri, as governor of Aden. Al-Bakri served as deputy to the former governor, Abdulaziz bin Habtoor, who fled the embattled city earlier this year. Al-Bakri is joined by the exiled deputy minister of health and the transportation and interior ministers, who have flown into Aden two days ago from Saudi Arabia. Other exiled ministers will follow suit over the next few weeks, Badie said.
On Monday evening, a car bomb went off near the house of a Houthi rebel leader in the capital Sanaa, killing seven and damaging the gates of the house, according to witnesses and officials.
It was not immediately clear if the Houthi leader, Ihab al-Kuhlani, was at home at the time of the attack and whether he was affected by the bombing.
The Houthi tv station Al-Masirah reported only that a car bomb went off in the Garef Neighborhood, without offering further details.
The area around the house was cordoned off by Houthi security forces after the attack.
Yemen's conflict pits the Iran-allied Houthis and troops loyal to the former president, Saleh, against an array of forces, including southern separatists, local and tribal militias, Sunni Islamic militants as well as loyalists of exiled President Abed Rabbo Mansour Hadi, who is backed internationally.

