Neither Spurs nor City have any suspension issues to worry about, with yellow cards wiped at this stage of the competition.
Fernando Llorente should be back from concussion, but Eric Dier (groin) and Erik Lamela (hamstring) are out, while Serge Aurier (hamstring) is unlikely to recover in time.
Tottenham XI: Lloris, Trippier, Alderweireld, Vertonghen, Davies, Sissoko, Alli, Eriksen, Son, Rose, Kane
Sergio Aguero faces a crunch 48 hours to be fit. The striker is still to train since suffering a muscular strain against Fulham last week.
Pep Guardiola hoped he would be able to play some part in Saturday’s FA Cup semi-final win against Cardiff – but was advised against involving the Argentine by club doctors.
If Aguero fails to come through training on Sunday, Guardiola faces the prospect of going into Tuesday’s game without his talismanic striker.
Kyle Walker will also be assessed after suffering a hamstring strain on Saturday.
Benjamin Mendy’s return to fitness is a boost is a boost for City with Oleksandr Zinchenko and Fabian Delph both injured.
Man City XI: Ederson, Walker, Laporte, Otamendi, Mendy, Gundogan, Fernandinho, De Bruyne, Bernardo Silva, Sterling, Aguero
Score prediction: Tottenham 1-1 Man City
Man City won 1-0 at Wembley in the Premier League earlier this season, and will be confident of scoring at least one away goal in the first leg.
However, Spurs will surely be buoyed by the prospect of playing at their new stadium, and have earned some famous European home wins in recent years.
With neither manager likely to commit to the tie on the night, it could be a cagey affair to set up a second-leg shootout in Manchester.
Match odds
Tottenham to win: 16/5
Draw: 14/5
Man City to win: 10/11
Tie odds
Tottenham to qualify: 7/2
Man City to qualify: 1/5
First goalscorer odds
Gabriel Jesus: 5/1
Harry Kane: 5/1
Sergio Aguero: 7/2
Heung-min Son: 17/2
Fernando Llorente should be back from concussion, but Eric Dier (groin) and Erik Lamela (hamstring) are out, while Serge Aurier (hamstring) is unlikely to recover in time.
Tottenham XI: Lloris, Trippier, Alderweireld, Vertonghen, Davies, Sissoko, Alli, Eriksen, Son, Rose, Kane
Pep Guardiola hoped he would be able to play some part in Saturday’s FA Cup semi-final win against Cardiff – but was advised against involving the Argentine by club doctors.
If Aguero fails to come through training on Sunday, Guardiola faces the prospect of going into Tuesday’s game without his talismanic striker.
Kyle Walker will also be assessed after suffering a hamstring strain on Saturday.
Benjamin Mendy’s return to fitness is a boost is a boost for City with Oleksandr Zinchenko and Fabian Delph both injured.
Man City XI: Ederson, Walker, Laporte, Otamendi, Mendy, Gundogan, Fernandinho, De Bruyne, Bernardo Silva, Sterling, Aguero
Score prediction: Tottenham 1-1 Man City
Man City won 1-0 at Wembley in the Premier League earlier this season, and will be confident of scoring at least one away goal in the first leg.
However, Spurs will surely be buoyed by the prospect of playing at their new stadium, and have earned some famous European home wins in recent years.
With neither manager likely to commit to the tie on the night, it could be a cagey affair to set up a second-leg shootout in Manchester.
Match odds
Tottenham to win: 16/5
Draw: 14/5
Man City to win: 10/11
Tie odds
Tottenham to qualify: 7/2
Man City to qualify: 1/5
First goalscorer odds
Gabriel Jesus: 5/1
Harry Kane: 5/1
Sergio Aguero: 7/2
Heung-min Son: 17/2
